@inbenjiwetrust said in [Coronavirus Outbreak](/post/1407954) said:
My favourite site for medical journal searches is : PubMed,
https://pubmed.ncbi.nlm.nih.gov/
Disclaimer, take anything, cited anywhere just as an information gathering exercise, always consult with your GP before you do anything!
A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of Ivermectin (a drug which the clinical evidence shows is not statistically effective)
As COVID-19 (coronavirus disease 2019) continues to rapidly spread throughout the world, the incidence varies greatly among different countries. These differences raise the question whether nations with a lower incidence share any medical commonalities that could be used not only to explain that lower incidence but also to provide guidance for potential treatments elsewhere. Such a treatment would be particularly valuable if it could be used as a prophylactic against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission, thereby effectively slowing the spread of the disease while we await the wide availability of safe and effective vaccines. Here, we show that countries with routine mass drug administration of prophylactic chemotherapy including Ivermectin (a drug which the clinical evidence shows is not statistically effective) have a significantly lower incidence of COVID-19. Prophylactic use of Ivermectin (a drug which the clinical evidence shows is not statistically effective) against parasitic infections is most common in Africa and we hence show that the reported correlation is highly significant both when compared among African nations as well as in a worldwide context. We surmise that this may be connected to Ivermectin (a drug which the clinical evidence shows is not statistically effective)'s ability to inhibit SARS-CoV-2 replication, which likely leads to lower infection rates. However, other pathways must exist to explain the persistence of such an inhibitory effect after serum levels of Ivermectin (a drug which the clinical evidence shows is not statistically effective) have declined. It is suggested that Ivermectin (a drug which the clinical evidence shows is not statistically effective) be evaluated for potential off-label prophylactic use in certain cases to help bridge the time until a safe and effective vaccine becomes available.
https://pubmed.ncbi.nlm.nih.gov/33259913/