@strongee said in [Coronavirus Outbreak](/post/1301436) said:
@tiger5150 said in [Coronavirus Outbreak](/post/1301393) said:
@strongee said in [Coronavirus Outbreak](/post/1301340) said:
>So many people just dismiss they opposing view , no matter whether the person put a lot of thought into it. You’re a lefty , do gooder from the right , and your a racist bogan from the left . Both wanting the other side silenced . I know it’s not really relevant to this , but I personally worry when I see this stuff .
This polarising binary of speech now removes all nuance from discussions. IMO it is a consequence of the politicisation of everything (particulary in the US), red team v blue team.
COVID vaccines are the perfect example. Its either the VACCINE IS PROVEN TO BE SAFE or the only other response is YOU SHOULD NOT TAKE THE VACCINE ANTIVAX view. Neither side of this binary is correct or tells the whole story. The vaccines are not proven to be safe, there has been no longitudinal studies done on the safety of them, but they have been proven (within acceptable parameters) to be safe in the short term. The choices people make are for their individual and community benefit, but it seems the media and social media narrative regarding it is that the community is incapable of discussing or making decisions as adults.
Im not an antivaxer, if/when my time comes I'll stick my arm out for the Oxford/Astra Zenaca vaccine(only).
Yep . Me too . So will my kids . But the conversation around how safe the vaccines are needs to be had . Especially if some unforeseen side effect rears it’s ugly head in the future .
I am a drug development project manager and I've been in the industry for 17 years. My company does contract work and we managed the Pfizer COVID vaccine study in the US, as well as the Novavax study (I did not work on it personally).
I don't really understand the comments about having a public "conversation" over the safety of vaccines. Your average person is not qualified to assess drug safety, nor does your average person understand the biostatistical analysis of trial data. The people who approve drugs for general consumption ARE the people who have expertise in the matter. So if a regulatory body deems that a drug is proven sufficiently safe, then that's about as good as you are going to get. Involving lay people in the discussion isn't really helpful.
By all means, do your own research on vaccines. The information is freely available. Do your research on everything, not just health. But also, you have to trust that the people who approve vaccines for general consumption are experts at doing so. Same as they approve other types of drugs for the general public, which aren't under scrutiny like vaccines are.
Or - don't trust the process, if you prefer, but understand that the process applies to ALL drugs, not just vaccines. So anti-vaxxers should also be wary of headache tablets, muscle relaxants, laxatives, cancer medications etc.
That's not to accuse anyone here of being an anti-vaxxer, just to give context about the process of developing and approving drugs - all drugs. I'm never quite clear why vaccines specifically have so much public focus. Or more correctly, I know that one guy published an article linking vaccines with autism many years ago, but that has been entirely hosed-down and I'm not sure why folks continue to worry more about vaccines than other medications. We've been giving shots to kids for a long time and the primary outcome has been near total eradication of a wide variety of illnesses that used to cause significant childhood mortality and morbidity.
People have to understand that the COVID vaccines are not being rushed or pushed through irresponsibly, despite political and social pressure to get the work done. In fact, these trials are getting much more medical and safety attention than any average trial would. Part of the reason the trials appear to be occurring quickly is because many of the red-tape hurdles have been removed. It's also proving much easier to get people to sign up for COVID trials than your average trial.
Furthermore, most, if not all, of the vaccines being applied to COVID are based on existing research/technologies. So pharma companies didn't have to wait to ramp up their trial abilities: they had the technology available once COVID was profiled/mapped.
For example the Pfizer/BioNTech vaccine, they've been fooling around with the technology for years. Once they isolated COVID they were ready to go, and my company has a pre-existing partnership for managing Pfizer clinical trials, so they rolled out a protocol for my company to start work on. The protocol designs are usually very similar; you basically drop the study into the existing framework and get going.
Secondary to the trial design, part of taking any medication is being reliably informed of the risk-benefit profile by a medical professional. But that's not a public debate, that's a discussion you have with your doctor. That's also the reason they stick the little paper pamphlets in every single prescription medication, with warnings all over the box. That IS the safety discussion.
If you are in doubt, like with anything, do your own research and discuss with a professional. There's plenty of easily-accessible and transparent information available online regarding COVID vaccines and their clinical trials:
Lastly in terms of long-term safety studies, I don't know how realistic that is. I don't mean from the POV of time elapsed, I simply mean due to the nature of vaccine delivery. Most drugs with long-term safety profiles are subscription products - i.e. you take them continuously for long periods. With vaccines, you treatment is normally over after a few weeks max, and typically side-effects present within a few days (e.g. injection-site reactions, allergies etc.). Vaccines have been well-studied over a very long period of time, so pharma companies have become pretty good at anticipating and managing side-effects, most of which tend to be quite benign.
Vaccines work to elicit an immune response, so they are typically quite weak products and it's your body that does the heavy lifting. Seriously, do the research on known and predicted adverse reactions to any/all vaccines and you will see the same fairly modest stuff over and over - headache, joint ache, injection-site swelling, chills, tiredness etc.
Consider it like drinking alcohol - the difference between the safety of drinking a lot of alcohol in a short period vs over a very long-period. The outcomes here are very different and there's no specific reason to expect that having 20 beers in one week will set you up for life-long outcomes.
Statistically, I think its very very unlikely we are going to see serious unexpected long-term adverse reactions from COVID vaccines. That's not to say we don't continue to do the safety analysis work (for example, the Pfizer study is collecting safety events for 2 years post dose, so it is ongoing), but just to realise it's a precaution and there is not any specific rationale to wait for more data before folks start getting their shots.