Target them around the ruck in attack. Roosters might have a touch more size than the Tigers, but with Farah controlling things around the ruck, the Tigers need to work on a quick play the ball and have Gallant sniffing around for any offloads. Tigers have a clear edge in the backline and with Moltzen and Benji in good form, we've got options both sides of the ruck. I'd definitely be sending plenty of ball down the left side to Lawrence and Tuiaki but Ayshford is also proving difficult to handle and he could be dangerous close to the line out wide with his long stride.
In defence, up and in again like last week, this will help shut down Mason too, the less room he ha to move, the better. The Roosters are going to rely on Pearce for their major attacking plays so put plenty of pressure on him all game and watch for Minichello and Perrett sniffing around the ruck and chiming in out wide. A good kick and chase is essential because Perrett is pretty quick and breaks plenty of tackles.
Tigers wingers will need to watch for Pearce's kicking game too, when he's on song he's dangerous, but if he can be put off his game early, and the Roosters go forard nullified, then the Tigers have too many options for the Roosters IMO.